4/10/2023 0 Comments Microvascular fragments meaning![]() These volumes, as you know, are typically provided to us by almost all post-processing perfusion softwares, and so this ratio can be easily calculated in the acute setting. What is HIR? It's a long name for a simple ratio that can easily be measured by dividing the volume of tissue with Tmax delay of over 10 seconds to the volume of tissue with Tmax delays of over 6 seconds. In this issue of the journal, we learn about another imaging marker that can potentially predict parenchymal hemorrhage occurrence post-endovascular therapy, which is high hypoperfusion intensity ratio, or HIR, as measured by perfusion imaging. But in the recent years, other radiographic markers of tissue viability, such as a poor collateral status and unfavorable venous outflow profile, have been shown to be predictors of post-reperfusion hemorrhagic transformation. For many years now, we've known about some of these predictors, such as presence of a large infarct core and high blood glucose levels. Symptomatic intracerebral hemorrhage is a feared complication of reperfusion therapies in acute stroke, so there's a lot of interest in looking for predictors of development of this complication, especially when you're making decisions for pursuing endovascular therapy. Nastajjia Krementz and Eric Goldstein, here's our article selection for the month of January. I'm an Associate Professor of Neurology at the University of Miami Miller School of Medicine and your host for the monthly Stroke Alert Podcast. Welcome back to another issue of the Stroke Alert Podcast. We're covering the latest in cerebrovascular disorders, and this is the best in Stroke. We'll be answering these questions and much more in today's podcast. Negar Asdaghi: Let's start with some questions.ġ) When during pregnancy is an intracranial aneurysm at the highest risk of rupture?Ģ) What does the presence of covert brain infarcts mean in the setting of atrial fibrillation?ģ) And, finally, how is the inflammatory form of cerebral amyloid angiopathy different from the classic CAA form, and why is it important to differentiate between the two? Georgios Tsivgoulis about his article ? Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis.?ĭr. Negar Asdaghi highlights two articles from the January 2023 issue of Stroke: ? Covert Brain Infarction as a Risk Factor for Stroke Recurrence in Patients With Atrial Fibrillation? and ? Subarachnoid Hemorrhage During Pregnancy and Puerperium.? She also interviews Dr. If this succeeds, a multitude of future therapeutic applications may significantly benefit from the remarkable properties of MVF.On Episode 24 of the Stroke Alert Podcast, host Dr. The next challenging step is now the successful translation of all these promising experimental findings into clinical practice. Besides, multiple factors determining the vascularization capacity of MVF have been identified, including their tissue origin and cellular composition, the conditions for their short- and long-term storage, as well as their implantation site and the general health status and medication of the recipient. ![]() Moreover, they serve as vascularization units for musculoskeletal regeneration and implanted biomaterials as well as for the treatment of myocardial infarction and the generation of prevascularized tissue organoids. Accordingly, they have been used for many years in microcirculation research to study basic mechanisms of endothelial cell function, angiogenesis, and microvascular network formation in two- and three-dimensional environments. Adipose tissue-derived microvascular fragments (MVF) are functional vessel segments, which rapidly reassemble into new microvasculatures under experimental in vitro and in vivo conditions. ![]()
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